Tbx1<tm1Pa> Targeted Allele Detail MGI Mouse (MGI:2179190)

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Tbx1^tm1Pa
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Tbx1^tm1Pa
Name:	T-box 1; targeted mutation 1, Virginia Papaioannou
MGI ID:	MGI:2179190
Gene:	Tbx1 Location: Chr16:18399729-18409412 bp, - strand Genetic Position: Chr16, Syntenic
Alliance:	Tbx1^tm1Pa page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:70730
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		A loxP-flanked neomycin selection cassette replaced most of the coding region of the gene. (J:70730)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	224 assay results
In Structures Affected by this Mutation:	46 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Tbx1 Mutation:	36 strains or lines available

References

Original:	J:70730 Jerome LA, et al., DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nat Genet. 2001 Mar;27(3):286-91
All:	39 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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