Tff1<tm1Mrio> Targeted Allele Detail MGI Mouse (MGI:2179220)

Tff1^tm1Mrio
Targeted Allele Detail

Summary

Symbol:	Tff1^tm1Mrio
Name:	trefoil factor 1; targeted mutation 1, Marie-Christine Rio
MGI ID:	MGI:2179220
Synonyms:	mpS2-, TFF1^-
Gene:	Tff1 Location: Chr17:31380369-31384034 bp, - strand Genetic Position: Chr17, 15.8 cM
Alliance:	Tff1^tm1Mrio page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:35923
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: Exon 2 of this gene was disrupted by the insertion of a neo cassette via homologous recombination. Northern blot analysis detected mutant transcript from the stomachs of homozygous mutant animals. Western blot of gastric cytosol and immunohistochemistry of stomach from homozygous mutant animals did not detect protein product. (J:35923)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Tff1 Mutation:	16 strains or lines available

References

Original:	J:35923 Lefebvre O, et al., Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein [see comments]. Science. 1996 Oct 11;274(5285):259-62
All:	22 reference(s)

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