Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Olig1tm1(cre)Rth
Name:	oligodendrocyte transcription factor 1; targeted mutation 1, David H Rowitch
MGI ID:	MGI:2179311
Synonyms:	CreOlig1 Tg, Olig1-, Olig1-cre, OLIG1cre, Olig1-null;PGKneo, Olig1tm1Rth
Gene:	Olig1  Location: Chr16:91066660-91068821 bp, + strand  Genetic Position: Chr16, 52.67 cM
Alliance:	Olig1tm1(cre)Rth page

Germline Transmission:	Earliest citation of germline transmission: J:75868
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout, Recombinase) Mutations:    Insertion, Intragenic deletion   Olig1tm1(cre)Rth expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Olig1 (MGI:1355334)   Mutation details: The majority of the coding region for this gene was replaced with a cre-neo cassette via homologous recombination so that the cre coding sequence is joined in-frame to the endogenous gene's coding region immediately following the translation initiation site. In situ hybridization of spinal cord from homozygous mutant embryos did not detect transcripts from the endogenous gene. In spinal cord from E10.5-E12.5 embryos heterozygous for this allele and for the conditional (Cre recombinase activated) lacZ reporter allele Gt(ROSA)26Sortm1Sor, Xgal staining co-localized with in situ hybridizing mRNAs for motor neuron and oligodendrocyte markers; antibodies to beta-galactosidase co-localized with those to an oligodendrocyte marker, but not to an astrocyte marker. (J:75868)

Activity:	Tissue activity of this recombinase allele
Driver:	Olig1 (mouse) Summary of all recombinase alleles driven by Olig1. Comparative matrix view of recombinase activities Alliance mouse Olig1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	104078 assay results 9 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Olig1 Mutation:	14 strains or lines available

Original:	J:75868 Lu QR, et al., Common developmental requirement for olig function indicates a motor neuron/oligodendrocyte connection. Cell. 2002 Apr 5;109(1):75-86
All:	87 reference(s)