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Sox17tm1Ysk
Targeted Allele Detail
Summary
Symbol: Sox17tm1Ysk
Name: SRY (sex determining region Y)-box 17; targeted mutation 1, Yoshiakira Kanai
MGI ID: MGI:2179440
Synonyms: Sox17-
Gene: Sox17  Location: Chr1:4561154-4567577 bp, - strand  Genetic Position: Chr1, 1.65 cM
Alliance: Sox17tm1Ysk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75946
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exons 2-4 were replaced with a PGK-neo cassette by homologous recombination. Western blot of E7.5 homozygous mutant embryos verified absence of encoded protein. (J:75946)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 177 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox17 Mutation:  29 strains or lines available
References
Original:  J:75946 Kanai-Azuma M, et al., Depletion of definitive gut endoderm in Sox17-null mutant mice. Development. 2002 May;129(10):2367-79
All:  13 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory