Fcgr4 MGI Mouse Gene Detail - MGI:2179523 - Fc receptor, IgG, low affinity IV

Symbol

Fcgr4
Name

Fc receptor, IgG, low affinity IV
Synonyms

4833442P21Rik, CD16-2, FcgammaRIV, Fcgr3a

Feature Type

protein coding gene
IDs

MGI:2179523
NCBI Gene: 246256
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr1:170846495-170857330 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 78.53 cM
Mapping Data

3 experiments

SNPs within 2kb

380 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2179523	protein coding gene	Chr1:170846489-170857330 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016739	protein coding gene	Chr1:176772471-176783337 (+)
A/J	MGP_AJ_G0016719	protein coding gene	Chr1:169560700-169571617 (+)
AKR/J	MGP_AKRJ_G0016685	protein coding gene	Chr1:174655996-174666796 (+)
BALB/cJ	MGP_BALBcJ_G0016680	protein coding gene	Chr1:170037453-170048277 (+)
C3H/HeJ	MGP_C3HHeJ_G0016503	protein coding gene	Chr1:174894077-174905360 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017141	protein coding gene	Chr1:182623845-182634676 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014850	protein coding gene	Chr1:161278656-161288966 (+)
CAST/EiJ	MGP_CASTEiJ_G0016084	protein coding gene	Chr1:174526803-174540323 (+)
CBA/J	MGP_CBAJ_G0016478	protein coding gene	Chr1:189122459-189133674 (+)
DBA/2J	MGP_DBA2J_G0016585	protein coding gene	Chr1:168409938-168420997 (+)
FVB/NJ	MGP_FVBNJ_G0016581	protein coding gene	Chr1:166771177-166782483 (+)
LP/J	MGP_LPJ_G0016656	protein coding gene	Chr1:177892090-177903006 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016608	protein coding gene	Chr1:196417183-196428153 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017178	protein coding gene	Chr1:174539466-174550865 (+)
PWK/PhJ	MGP_PWKPhJ_G0015870	protein coding gene	Chr1:167652887-167663806 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015654	protein coding gene	Chr1:173293408-173307322 (+)
WSB/EiJ	MGP_WSBEiJ_G0016146	protein coding gene	Chr1:174661761-174672617 (+)

Human Ortholog

FCGR3A, Fc gamma receptor IIIa

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FCGR3A, Fc gamma receptor IIIa
Synonyms

CD16, CD16A, CD16-II, FCG3, FCGR3, FCGRIII, FcGRIIIA, FCR-10, FCRIII, FCRIIIA, IGFR3, IMD20
Links

HGNC:3619

NCBI Gene ID: 2214

neXtProt AC: NX_P08637

UniProt: P08637
Chr Location

1q23.3; chr1:161541759-161550968 (-) GRCh38

Human Ortholog

FCGR3B, Fc gamma receptor IIIb
Synonyms

CD16, CD16A, CD16b, CD16-I, FCG3, FCGR3, FCGR3A, FCR-10, FCRIII, FCRIIIb
Links

HGNC:3620

NCBI Gene ID: 2215

neXtProt AC: NX_O75015

UniProt: O75015
Chr Location

1q23.3; chr1:161623196-161631963 (-) GRCh38

MGI Vertebrate Homology

Fcgr4 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FCGR3A, FCGR3B
Gene Tree

Fcgr4

Diseases

25 with human FCGR3A associations

				Human Disease	Mouse Models
				allergic disease IDs allergic disease DOID:1205 ICD10CM:T78.40 MESH:D006967 NCI:C3114 UMLS_CUI:C0020517
				allergic rhinitis IDs allergic rhinitis DOID:4481 DOID:12089 DOID:14030 DOID:8241 DOID:8242 EFO:0003956 NCI:C34987 OMIM:607154 UMLS_CUI:C0002103
				anti-basement membrane glomerulonephritis IDs anti-basement membrane glomerulonephritis DOID:4780 NCI:C35798 UMLS_CUI:C1332309
				arthritis IDs arthritis DOID:848 ICD10CM:M19.90 MESH:D001168 NCI:C2883 UMLS_CUI:C0003864
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				autoimmune thrombocytopenic purpura IDs autoimmune thrombocytopenic purpura DOID:8924 DOID:0050124 DOID:2220 ICD10CM:D69.3 ICD9CM:287.31 MESH:D016553 NCI:C3446 OMIM:188030 UMLS_CUI:C0398650
				Behcet's disease IDs Behcet's disease DOID:13241 EFO:0003780 ICD10CM:M35.2 ICD9CM:136.1 ICD9CM_2006:136.1 MESH:D001528 NCI:C34416 OMIM:109650 UMLS_CUI:C0004943
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				Crohn's disease IDs Crohn's disease DOID:8778 DOID:8784 DOID:8855 DOID:8942 EFO:0000384 ICD10CM:K50.1 ICD9CM:555.1 MESH:D003424 NCI:C37262 UMLS_CUI:C0156147
				glomerulonephritis IDs glomerulonephritis DOID:2921 ICD10CM:N08 MESH:D005921 NCI:C26784 UMLS_CUI:C0017658
				graft-versus-host disease IDs graft-versus-host disease DOID:0081267 MESH:D006086 OMIM:614395 ORDO:39812
				human immunodeficiency virus infectious disease IDs human immunodeficiency virus infectious disease DOID:526 ICD10CM:B20 ICD9CM:042 ICD9CM:042-042.99 MESH:D015658 NCI:C3108 UMLS_CUI:C0019693
				IgA glomerulonephritis IDs IgA glomerulonephritis DOID:2986 EFO:0004194 MESH:D005922 NCI:C34643 OMIM:161950 UMLS_CUI:C0017661
				immunodeficiency 20 IDs immunodeficiency 20 DOID:0111941 OMIM:615707 ORDO:437552
				lymphopenia IDs lymphopenia DOID:614 ICD10CM:D72.810 ICD9CM:288.51 MESH:D008231 UMLS_CUI:C0024312
				lymphoplasmacytic lymphoma IDs lymphoplasmacytic lymphoma DOID:0060901 ICD10CM:C88.0 MESH:D008258 NCI:C115212 NCI:C80307 OMIM:153600 OMIM:610430 ORDO:33226 UMLS_CUI:C0024419 UMLS_CUI:C2936755
				myelodysplastic syndrome IDs myelodysplastic syndrome DOID:0050908 MESH:D009190 OMIM:614286 UMLS_CUI:C2713368
				myositis IDs myositis DOID:633 ICD10CM:M60 MESH:D009220 NCI:C27578 OMIM:160750 UMLS_CUI:C0027121
				pneumonia IDs pneumonia DOID:552 DOID:10509 DOID:11742 DOID:5871 MESH:D011014 NCI:C3333 UMLS_CUI:C0032285
				polyneuropathy IDs polyneuropathy DOID:1389 ICD10CM:A69.22 MESH:D011115 NCI:C26951 UMLS_CUI:C0152025
				rheumatoid arthritis IDs rheumatoid arthritis DOID:7148 EFO:0000685 ICD10CM:M06.9 ICD9CM:714.0 KEGG:05323 MESH:D001172 NCI:C2884 OMIM:180300 UMLS_CUI:C0003873
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141
				temporal arteritis IDs temporal arteritis DOID:13375 ICD9CM:446.5 MESH:D013700 NCI:C35065 OMIM:187360 ORDO:397 UMLS_CUI:C0039483
				thrombocytopenia due to platelet alloimmunization IDs thrombocytopenia due to platelet alloimmunization DOID:1587 NCI:C3991 UMLS_CUI:C0272286
				visual epilepsy IDs visual epilepsy DOID:11832 MESH:D012640 NCI:C3980 UMLS_CUI:C0270824

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 2 alleles in 1 genetic background
1 images
49 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

2
Endonuclease-mediated

8
Gene trapped

1
Targeted

7
Genomic Mutations

6 involving Fcgr4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased susceptibility to induced arthritis and nephrotoxic nephritis.

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All GO Annotations

29
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

7
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS15476.1

Ensembl

ENSMUSG00000059089 (Evidence)
NCBI Gene

246256

			Length	Strain/Species	Flank
genomic	246256	NCBI Gene Model \| MGI Sequence Detail	10836	C57BL/6J	± kb
transcript	NM_144559	RefSeq \| MGI Sequence Detail	1250	ZRU/MplStud
polypeptide	A0A0B4J1G0	UniProt \| EBI \| MGI Sequence Detail	249	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001485 low affinity immunoglobulin gamma Fc region receptor III-B

(term hierarchy)
InterPro Domains

IPR050488 Immunoglobulin Fc region receptor

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2
GlyGen

A0A0B4J1G0 3 sites, 1 N-linked glycan (1 site)

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All nucleic 8

cDNA 7

Primer pair 1

Microarray probesets 2

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MGI:2443436

Summaries

All 90

Developmental Gene Expression 2

Gene Ontology 12

Phenotypes 49
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:357461 Liu Y, et al., Features and protective efficacy of human mAbs targeting Mycobacterium tuberculosis arabinomannan. JCI Insight. 2023 Oct 23;8(20)

TSS for Fcgr4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9942	Chr1:170845596-170845642 (+)	-876 bp
Tssr9943	Chr1:170846465-170846477 (+)	-24 bp
Tssr9944	Chr1:170846492-170846499 (+)	1 bp
Tssr9945	Chr1:170846510-170846548 (+)	34 bp
Tssr9946	Chr1:170847415-170847428 (+)	927 bp
Tssr9947	Chr1:170847431-170847442 (+)	942 bp
Tssr9948	Chr1:170847536-170847553 (+)	1,050 bp
Tssr9949	Chr1:170851240-170851242 (+)	4,746 bp
Tssr9950	Chr1:170853148-170853162 (+)	6,660 bp
Tssr9952	Chr1:170856806-170856824 (+)	10,320 bp
Tssr9953	Chr1:170856872-170856884 (+)	10,383 bp
Tssr9954	Chr1:170856912-170856925 (+)	10,424 bp
Tssr9955	Chr1:170856935-170856954 (+)	10,450 bp
Tssr9956	Chr1:170856957-170856972 (+)	10,470 bp
Tssr9957	Chr1:170856981-170856994 (+)	10,493 bp
Tssr9958	Chr1:170857000-170857007 (+)	10,509 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24