RelbTg(H2-K1/GH1)106Bri
Transgenic Allele Detail
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| Symbol: |
RelbTg(H2-K1/GH1)106Bri |
| Name: |
avian reticuloendotheliosis viral (v-rel) oncogene related B; transgene insertion 106, Ralph L Brinster |
| MGI ID: |
MGI:2179544 |
| Synonyms: |
272H, line 272-4, relb-, RelbTg106Bri, RelbTg(H2K/GH1)106Bri, Tg(H-2K + GH1), Tg(H-2K +GH1)Bri106, Tg(H2KhGH1)106Bri |
| Gene: |
Relb Location: Chr7:19340142-19363352 bp, - strand Genetic Position: Chr7, 9.93 cM
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| Alliance: |
RelbTg(H2-K1/GH1)106Bri page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence, Null/knockout) |
| Mutation: |
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Insertion
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Mutation details: The mutation was generated by microinjection of a construct containing a 7.8 kb fragment that includes the complete mouse H2-K structural locus and 2 kb of 5' flanking sequence, as well as a nonfunctional 2.1 kb portion of the human growth hormone gene (hGH1), which serves as a marker gene. The random insertion of this transgene just downstream of the exon encoding the Rel domain disrupted the gene. RT-PCR analysis of RNA derived from slpeen and thymus of homozygous mice demonstrated that no detectable transcript was expressed from this allele. Immunohistochemistry experiments on sections of thymus and spleen of homozygous mice confirmed that no detectable encoded protein was present.
(J:23081)
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| Inheritance: |
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Recessive |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:76450 Lo D, et al., A recessive defect in lymphocyte or granulocyte function caused by an integrated transgene. Am J Pathol. 1992 Nov;141(5):1237-46 |
| All: |
29 reference(s) |
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Analysis Tools
