Relb<tm1Brv> Targeted Allele Detail MGI Mouse (MGI:2179545)

Relb^tm1Brv
Targeted Allele Detail

Summary

Symbol:	Relb^tm1Brv
Name:	avian reticuloendotheliosis viral (v-rel) oncogene related B; targeted mutation 1, Rodrigo Bravo
MGI ID:	MGI:2179545
Synonyms:	Relb-, RelB^KO
Gene:	Relb Location: Chr7:19340142-19363352 bp, - strand Genetic Position: Chr7, 9.93 cM
Alliance:	Relb^tm1Brv page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:22675
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin resistance gene replaced a 0.5 kb fragment containing most of exon 4, which encodes the beginning of the Rel homology domain. Western blot analysis on lysates derived from homozygous mice confirmed that no detectable protein was present. (J:22675)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Relb Mutation:	33 strains or lines available

References

Original:	J:22675 Weih F, et al., Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family. Cell. 1995 Jan 27;80(2):331-40
All:	45 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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