Prkcd<tm1Kin> Targeted Allele Detail MGI Mouse (MGI:2179710)

Prkcd^tm1Kin
Targeted Allele Detail

Summary

Symbol:	Prkcd^tm1Kin
Name:	protein kinase C, delta; targeted mutation 1, Kei-ichi Nakayama
MGI ID:	MGI:2179710
Synonyms:	nPKDdelta^-, PCK-delta-, PKCdelta^-
Gene:	Prkcd Location: Chr14:30317311-30348167 bp, - strand Genetic Position: Chr14, 18.82 cM
Alliance:	Prkcd^tm1Kin page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:76135
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exons 1 and 2 were replaced with a neomycin resistance gene via homologous recombination. Protein product was absent in brain of homozygous mutant animals as determined by Western blot analysis. (J:76135)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background
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hm1	Prkcd^tm1Kin/Prkcd^tm1Kin	involves: 129P2/OlaHsd
hm2	Prkcd^tm1Kin/Prkcd^tm1Kin	involves: 129P2/OlaHsd * C57BL/6
cx3	Blnk^tm1Dkit/Blnk^tm1Dkit Prkcd^tm1Kin/Prkcd^tm1Kin	involves: 129P2/OlaHsd * C57BL/6 * NZB

Phenotypes:

Affected Systems	hm1	hm2	cx3
show or hide all annotated terms
cellular	√	√	√
increased B cell apoptosis			√
abnormal osteoblast differentiation	√
abnormal B cell proliferation			√
increased B cell proliferation		√
endocrine/exocrine glands		√
abnormal pancreatic beta cell morphology		√
decreased insulin secretion		√
growth/size/body		√
decreased body weight		√
enlarged spleen		√
hematopoietic system		√	√
increased B cell apoptosis			√
abnormal B cell proliferation			√
increased B cell proliferation		√
enlarged spleen		√
abnormal plasma cell differentiation		√	√
arrested B cell differentiation			√
decreased B-1 B cell number			√
decreased B-2 B cell number			√
decreased follicular B cell number			√
decreased marginal zone B cell number			√
increased B cell number		√
increased transitional stage B cell number		√
increased follicular B cell number		√
increased marginal zone B cell number		√
increased spleen germinal center number		√
abnormal immunoglobulin level		√	√
increased IgA level		√	√
increased IgG1 level		√	√
increased IgG2b level			√
increased IgG3 level			√
increased IgM level		√	√
homeostasis/metabolism		√
decreased insulin secretion		√
impaired glucose tolerance		√
immune system		√	√
increased B cell apoptosis			√
abnormal B cell proliferation			√
increased B cell proliferation		√
enlarged spleen		√
abnormal plasma cell differentiation		√	√
arrested B cell differentiation			√
decreased B-1 B cell number			√
decreased B-2 B cell number			√
decreased follicular B cell number			√
decreased marginal zone B cell number			√
increased B cell number		√
increased transitional stage B cell number		√
increased follicular B cell number		√
increased marginal zone B cell number		√
increased spleen germinal center number		√
abnormal immunoglobulin level		√	√
increased IgA level		√	√
increased IgG1 level		√	√
increased IgG2b level			√
increased IgG3 level			√
increased IgM level		√	√
abnormal Peyer's patch germinal center morphology		√
abnormal lymph node germinal center morphology		√
enlarged lymph nodes		√
increased interleukin-6 secretion		√
increased anti-chromatin antibody level		√
increased acute inflammation		√
glomerulonephritis		√
renal/urinary system		√
glomerulonephritis		√
renal glomerular immunoglobulin deposits		√
skeleton	√
abnormal osteoblast differentiation	√
decreased width of hypertrophic chondrocyte zone	√
abnormal bone ossification	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Prkcd Mutation:	54 strains or lines available

References

Original:	J:76135 Miyamoto A, et al., Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature. 2002 Apr 25;416(6883):865-9
All:	42 reference(s)

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