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Plaat3 Gene Detail
Summary
  • Symbol
    Plaat3
  • Name
    phospholipase A and acyltransferase 3
  • Synonyms
    Hrasls3, Pla2g16
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179715
    NCBI Gene: 225845
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:7534824-7565910 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    898 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179715
 protein coding gene Chr19:7534824-7565914 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024794
 protein coding gene Chr19:4704739-4737845 (+)
A/J MGP_AJ_G0024761
 protein coding gene Chr19:4352331-4384017 (+)
AKR/J MGP_AKRJ_G0024734
 protein coding gene Chr19:4473974-4505871 (+)
BALB/cJ MGP_BALBcJ_G0024761
 protein coding gene Chr19:4450670-4483865 (+)
C3H/HeJ MGP_C3HHeJ_G0024528
 protein coding gene Chr19:4609238-4640933 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025207
 protein coding gene Chr19:4805495-4835584 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022641
 protein coding gene Chr19:4243204-4274546 (+)
CAST/EiJ MGP_CASTEiJ_G0024001
 protein coding gene Chr19:4522998-4554427 (+)
CBA/J MGP_CBAJ_G0024501
 protein coding gene Chr19:4869530-4901092 (+)
DBA/2J MGP_DBA2J_G0024628
 protein coding gene Chr19:4300379-4331640 (+)
FVB/NJ MGP_FVBNJ_G0024593
 protein coding gene Chr19:4342806-4374018 (+)
LP/J MGP_LPJ_G0024714
 protein coding gene Chr19:4553926-4585330 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024623
 protein coding gene Chr19:4769980-4805198 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025255
 protein coding gene Chr19:4643600-4675201 (+)
PWK/PhJ MGP_PWKPhJ_G0023747
 protein coding gene Chr19:4366757-4398482 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023551
 protein coding gene Chr19:4438132-4469611 (+)
WSB/EiJ MGP_WSBEiJ_G0024063
 protein coding gene Chr19:4534465-4565208 (+)



Homology
more
  • Human Ortholog
    PLAAT3, phospholipase A and acyltransferase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLAAT3, phospholipase A and acyltransferase 3
  • Synonyms
    AdPLA, FPLD9, HRASLS3, H-REV107, HREV107, H-REV107-1, HREV107-1, HREV107-3, HRSL3, PLA2G16, PLAAT-3
  • Links
    NCBI Gene ID: 11145
    neXtProt AC: NX_P53816
    UniProt: P53816

  • Chr Location
    11q12.3-q13.1; chr11:63573195-63616927 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased lipolysis, decreased susceptibility to diet- or leptin deficiency-induced obesity, hepatic steatosis and altered glucose homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060675 Ensembl Gene Model | MGI Sequence Detail 31087 C57BL/6J ±  kb
    transcript ENSMUST00000136465 Ensembl | MGI Sequence Detail 3048 Not Applicable  
    polypeptide ENSMUSP00000119403 Ensembl | MGI Sequence Detail 168 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 29

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147787, MGI:6286251
    References
    more
    • Summaries
      All 48
      Gene Ontology 14
      Phenotypes 14
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory