Tbr1<tm1Jlr> Targeted Allele Detail MGI Mouse (MGI:2179766)

Tbr1^tm1Jlr
Targeted Allele Detail

Summary

Symbol:	Tbr1^tm1Jlr
Name:	T-box brain transcription factor 1; targeted mutation 1, John L Rubenstein
MGI ID:	MGI:2179766
Gene:	Tbr1 Location: Chr2:61633274-61644458 bp, + strand Genetic Position: Chr2, 35.56 cM
Alliance:	Tbr1^tm1Jlr page

Premature overgrowth and superabundance of subcortical axons in the brainstem of Tbr1^tm1Jlr/Tbr1^tm1Jlr Tg(Mbp-MAPT/EGFP)#Eja/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:51888
Parent Cell Line:	JM-1 (ES Cell)
Strain of Origin:	129X1/SvJ

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exons 2 and 3, which encode a putative DNA-binding domain, were replaced with a PGK-neo cassette via homologous recombination. Homozygous mutant animals were identified by Southern blot and PCR genotype analysis. (J:51888)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Tbr1 Mutation:	38 strains or lines available

References

Original:	J:51888 Bulfone A, et al., An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. Neuron. 1998 Dec;21(6):1273-82
All:	21 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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