Snta1tm1Scf
Targeted Allele Detail
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| Symbol: |
Snta1tm1Scf |
| Name: |
syntrophin, acidic 1; targeted mutation 1, Stanley C Froehner |
| MGI ID: |
MGI:2179769 |
| Synonyms: |
alpha-Syn -/-, alphaSynKO |
| Gene: |
Snta1 Location: Chr2:154218234-154250004 bp, - strand Genetic Position: Chr2, 76.52 cM
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| Alliance: |
Snta1tm1Scf page
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Snta1tm1Scf/Snta1tm1Scf mice exhibit abnormal neuromuscular junctions
Show the 2 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:76455
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| Parent Cell Line: |
E14 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exon 1, which encodes the first 97 amino acids including part of the PH domain and part of the PDZ domain. Northern blot analysis on RNA derived from skeletal muscle of homozygous mice demonstrated that aberrant transcripts were expressed from this allele, but immunoprecipitation experiments confirmed that no detectable encoded protein was present in skeletal muscle of homozygous mice.
(J:76455)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:76455 Adams ME, et al., Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin. J Cell Biol. 2000 Sep 18;150(6):1385-97 |
| All: |
38 reference(s) |
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Analysis Tools
