Xrcc6<tm1Fwa> Targeted Allele Detail MGI Mouse (MGI:2179954)

Xrcc6^tm1Fwa
Targeted Allele Detail

Summary

Symbol:	Xrcc6^tm1Fwa
Name:	X-ray repair complementing defective repair in Chinese hamster cells 6; targeted mutation 1, Frederick W Alt
MGI ID:	MGI:2179954
Synonyms:	Ku70-, Ku70DKO
Gene:	Xrcc6 Location: Chr15:81872036-81924286 bp, + strand Genetic Position: Chr15, 38.33 cM, cytoband E-F
Alliance:	Xrcc6^tm1Fwa page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:44361
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: 450 bp of this gene encompassing exon 4 and part of exon 5 were replaced with a neo cassette via homologous recombination resulting in a shift in the reading frame and predicted protein truncation after the first 64 residues. Homozygous mutant ES cells were identified by Southern blot analysis and Western blot analysis confirmed the absence of protein product. (J:41941, J:44361)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Xrcc6^tm1Fwa

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Xrcc6 Mutation:	63 strains or lines available

References

Original:	J:44361 Gu Y, et al., Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity. 1997 Nov;7(5):653-65
All:	35 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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