Ltbp3tm1Bdvc
Targeted Allele Detail
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| Symbol: |
Ltbp3tm1Bdvc |
| Name: |
latent transforming growth factor beta binding protein 3; targeted mutation 1, Branka Dabovic |
| MGI ID: |
MGI:2180017 |
| Synonyms: |
Ltbp-3-null |
| Gene: |
Ltbp3 Location: Chr19:5790932-5808560 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband B
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| Alliance: |
Ltbp3tm1Bdvc page
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Skeletal abnormalities in Ltbp3tm1Bdvc/Ltbp3tm1Bdvc mice
Show the 4 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:76213
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| Parent Cell Line: |
W4 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Two exons of this gene spanning nucleotides 278-807 were replaced with a neo resistance cassette, causing a frameshift in the ORF resulting in premature translation termination and deletion of the first EGF-like repeat, the pro-gly-rich region, and the beginning of the first 8-cys domain. Northern blot analysis of lung from homozygous mutant animals using a probe corresponding to the deleted exons failed to detect transcripts.
(J:76213)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ltbp3 Mutation: |
59 strains or lines available
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| Original: |
J:76213 Dabovic B, et al., Bone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailability. J Cell Biol. 2002 Jan 21;156(2):227-32 |
| All: |
13 reference(s) |
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Analysis Tools
