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Egr3tm1Jmi
Targeted Allele Detail
Summary
Symbol: Egr3tm1Jmi
Name: early growth response 3; targeted mutation 1, Jeffrey Milbrandt
MGI ID: MGI:2180063
Synonyms: Egr-3-, Egr3-
Gene: Egr3  Location: Chr14:70314766-70320062 bp, + strand  Genetic Position: Chr14, 36.2 cM, cytoband D1
Alliance: Egr3tm1Jmi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49575
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: A 0.9 kb region of the gene encoding the zinc-finger domain and C-terminus of the protein was disrupted by insertion of a neomycin resistance cassette. Northern and Western blot of brain from homozygous mutant animals failed to detect gene expression. (J:49575)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Egr3 Mutation:  17 strains or lines available
References
Original:  J:49575 Tourtellotte WG, et al., Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3. Nat Genet. 1998 Sep;20(1):87-91
All:  45 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory