Dnah5<Tg1Htz> Transgenic Allele Detail MGI Mouse (MGI:2180081)

Dnah5^Tg1Htz
Transgenic Allele Detail

Summary

Symbol:	Dnah5^Tg1Htz
Name:	dynein, axonemal, heavy chain 5; transgene insertion 1, Nathaniel Heintz
MGI ID:	MGI:2180081
Synonyms:	Mdnah5 -
Gene:	Dnah5 Location: Chr15:28203898-28472198 bp, + strand Genetic Position: Chr15, 10.9 cM
Alliance:	Dnah5^Tg1Htz page

Transgene
origin

Strain of Origin:

Transgene
description

Transgene Type:		Transgenic
Mutation:		Insertion
		Mutation details: This mutation resulted from the random integration of a transgene (not identified in paper). RT-PCR analysis demonstrated that a transcript with the transgene replacing sequences between exons 16 and 22 was expressed, resulting in the generation of a stop codon at the start of the transgene. The predicted translated product of this fusion transcript lacks all of the known functional domains of the protein. (J:76189)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Dnah5 Mutation:	252 strains or lines available

References

Original:	J:76189 Ibanez-Tallon I, et al., Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus. Hum Mol Genet. 2002 Mar 15;11(6):715-21
All:	2 reference(s)

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