Sh2b3<tm1Rmp> Targeted Allele Detail MGI Mouse (MGI:2180088)

Sh2b3^tm1Rmp
Targeted Allele Detail

Summary

Symbol:	Sh2b3^tm1Rmp
Name:	SH2B adaptor protein 3; targeted mutation 1, Roger M Perlmutter
MGI ID:	MGI:2180088
Synonyms:	lnk-
Gene:	Sh2b3 Location: Chr5:121953551-121975709 bp, - strand Genetic Position: Chr5, 61.99 cM
Alliance:	Sh2b3^tm1Rmp page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:66032
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The majority of the coding region was replaced with a neomycin resistance gene via homologous recombination. Northern blot analysis verified the absence of gene expression in homozygous mutant animals. (J:66032)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Sh2b3 Mutation:	24 strains or lines available

References

Original:	J:66032 Takaki S, et al., Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins. Immunity. 2000 Nov;13(5):599-609
All:	21 reference(s)

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