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Nefmtm1Jpj
Targeted Allele Detail
Summary
Symbol: Nefmtm1Jpj
Name: neurofilament, medium polypeptide; targeted mutation 1, Jean-Pierre Julien
MGI ID: MGI:2180106
Synonyms: NF-M-
Gene: Nefm  Location: Chr14:68356994-68362453 bp, - strand  Genetic Position: Chr14, 35.46 cM
Alliance: Nefmtm1Jpj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:56931
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The gene was disrupted by replacement of exon 1 with a neomycin resistance cassette via homologous recombination. Absence of gene expression was verified in Northern blots of brain from homozygous mutant animals. (J:56931)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nefm Mutation:  28 strains or lines available
References
Original:  J:56931 Jacomy H, et al., Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits. J Neurochem. 1999 Sep;73(3):972-84
All:  9 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory