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Angpt1tm2Sato
Targeted Allele Detail
Summary
Symbol: Angpt1tm2Sato
Name: angiopoietin 1; targeted mutation 2, Thomas Sato
MGI ID: MGI:2180145
Synonyms: Mu2
Gene: Angpt1  Location: Chr15:42288119-42540373 bp, - strand  Genetic Position: Chr15, 16.69 cM
Alliance: Angpt1tm2Sato page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:37459
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A promoterless lacZ-neo construct was used to disrupt exon 1, which is essential for function. Northern blot analysis using a probe for exon 1 revealed an absence of normal transcript in homozygous mutant embryos, however, lacZ was expressed from the endogenous promoter. (J:37459)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Angpt1 Mutation:  35 strains or lines available
References
Original:  J:37459 Suri C, et al., Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell. 1996 Dec 27;87(7):1171-80
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory