Snap25<tm1Mcw> Targeted Allele Detail MGI Mouse (MGI:2180178)

Snap25^tm1Mcw
Targeted Allele Detail

Summary

Symbol:	Snap25^tm1Mcw
Name:	synaptosomal-associated protein 25; targeted mutation 1, Michael C Wilson
MGI ID:	MGI:2180178
Synonyms:	Snap25-
Gene:	Snap25 Location: Chr2:136555373-136624348 bp, + strand Genetic Position: Chr2, 67.56 cM
Alliance:	Snap25^tm1Mcw page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:73755
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exon 5a/b and part of the downstream intron were replaced with a PGK-neo cassette by homologous recombination. Western blot of brain proteins and RT-PCR analysis of total brain RNA from homozygous mutant embryos verified the absence of gene expression. (J:73755)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Snap25 Mutation:	26 strains or lines available

References

Original:	J:73755 Washbourne P, et al., Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis. Nat Neurosci. 2002 Jan;5(1):19-26
All:	33 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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