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Scn10atm1Jwo
Targeted Allele Detail
Summary
Symbol: Scn10atm1Jwo
Name: sodium channel, voltage-gated, type X, alpha; targeted mutation 1, John N Wood
MGI ID: MGI:2180183
Synonyms: Nav1.8-, Scn10atm1Jnw, SNS-
Gene: Scn10a  Location: Chr9:119437522-119548388 bp, - strand  Genetic Position: Chr9, 71.33 cM, cytoband distal
Alliance: Scn10atm1Jwo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76456
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Part of exon 4 and all of exon 5, which encodes the S4 voltage sensor of domain I, were replaced with a PGK-neo cassette via homologous recombination. The PGK-neo cassette introduces stop codons in all 3 reading frames. RT-PCR analysis detected weak expression of mutant transcripts in homozygous mutant animals. (J:76456)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Scn10a Mutation:  102 strains or lines available
References
Original:  J:76456 Akopian AN, et al., The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat Neurosci. 1999 Jun;2(6):541-8
All:  28 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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12/10/2024
MGI 6.24 		The Jackson Laboratory