Sgcd<tm1Mcn> Targeted Allele Detail MGI Mouse (MGI:2180193)

Sgcd^tm1Mcn
Targeted Allele Detail

Summary

Symbol:	Sgcd^tm1Mcn
Name:	sarcoglycan, delta (dystrophin-associated glycoprotein); targeted mutation 1, Elizabeth M McNally
MGI ID:	MGI:2180193
Synonyms:	dsg^-, Scgd^-
Gene:	Sgcd Location: Chr11:46861904-47880309 bp, - strand Genetic Position: Chr11, 28.09 cM, cytoband B1.2
Alliance:	Sgcd^tm1Mcn page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:76730
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin selection cassette was used to replace exon 2, which encodes the translation initiation codon and the cytoplasmic and transmembrane domains. Northern analysis showed that message was not transcribed in skeletal muscle of homozygous mutant mice. The lack of protein in immunoblots further confirmed complete inactivation. (J:76730)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Sgcd Mutation:	22 strains or lines available

References

Original:	J:76730 Hack AA, et al., Differential requirement for individual sarcoglycans and dystrophin in the assembly and function of the dystrophin-glycoprotein complex. J Cell Sci. 2000 Jul;113(Pt 14):2535-44
All:	44 reference(s)

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