Ccl5tm1Hso
Targeted Allele Detail
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|
| Symbol: |
Ccl5tm1Hso |
| Name: |
C-C motif chemokine ligand 5; targeted mutation 1, Hiroshi Sato |
| MGI ID: |
MGI:2180195 |
| Synonyms: |
CCL5-KO, RANTES- |
| Gene: |
Ccl5 Location: Chr11:83416604-83421344 bp, - strand Genetic Position: Chr11, 50.66 cM
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| Alliance: |
Ccl5tm1Hso page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:75842
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| Parent Cell Line: |
E14 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 333 bp region of the gene containing the promoter, transcription and translation initiation sites, and part of exon 1 was replaced with a PGK-hygro cassette via homologous recombination. Northern blot analysis confirmed the absence of gene expression in homozygous mutant mice.
(J:75842)
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| Key: |
| hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/
Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
|---|
Loading... | | | involves: 129P2/OlaHsd * C57BL/6 | |
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| Phenotypes: |
| Affected Systems |
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cellular
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√
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decreased T cell proliferation
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√
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hematopoietic system
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√
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decreased T cell proliferation
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√
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decreased CD4-positive, alpha-beta T cell number
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√
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immune system
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√
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decreased T cell proliferation
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√
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decreased CD4-positive, alpha-beta T cell number
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√
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decreased susceptibility to type IV hypersensitivity reaction
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√
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decreased interferon-gamma secretion
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√
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decreased interleukin-2 secretion
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:75842 Makino Y, et al., Impaired T cell function in RANTES-deficient mice. Clin Immunol. 2002 Mar;102(3):302-9 |
| All: |
44 reference(s) |
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Analysis Tools
