Fertm1Pag
Targeted Allele Detail
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| Symbol: |
Fertm1Pag |
| Name: |
FER tyrosine kinase; targeted mutation 1, Peter A Greer |
| MGI ID: |
MGI:2180299 |
| Synonyms: |
ferD743R, ferDR |
| Gene: |
Fer Location: Chr17:64170057-64446491 bp, + strand Genetic Position: Chr17, 33.06 cM
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| Alliance: |
Fertm1Pag page
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| Allele Type: |
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Targeted (Not Specified) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: An aspartate to arginine mutation at position 743 (D743R) was introduced into exon 19 via homologous recombination in conjunction with a neo resistance cassette downstream of exon 20. The mutation is designed to inactivate the kinase domain by destabilizing the catalytic loop. Western blot analysis of homozygous mutant animals detected protein expression in testis but greatly reduced protein expression in liver. Kinase assays demonstrated complete absence of kinase activity in both testis and liver extracts from homozygous mutants.
(J:67350)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Fer Mutation: |
36 strains or lines available
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| Original: |
J:67350 Craig AW, et al., Mice devoid of fer protein-tyrosine kinase activity are viable and fertile but display reduced cortactin phosphorylation. Mol Cell Biol. 2001 Jan;21(2):603-13 |
| All: |
11 reference(s) |
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Analysis Tools
