Nhlh2<tm1Irk> Targeted Allele Detail MGI Mouse (MGI:2180391)

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Nhlh2^tm1Irk
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Nhlh2^tm1Irk
Name:	nescient helix loop helix 2; targeted mutation 1, Ilan R Kirsch
MGI ID:	MGI:2180391
Synonyms:	Nhlh2^-
Gene:	Nhlh2 Location: Chr3:101917425-101922808 bp, + strand Genetic Position: Chr3, 44.3 cM
Alliance:	Nhlh2^tm1Irk page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:39356
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The entire coding region was replaced with a PGK-neo cassette. Transcript was undetected by Northern blot analysis of total RNA isolated from homozygous mutant embryos. (J:39356)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Nhlh2 Mutation:	13 strains or lines available

References

Original:	J:39356 Good DJ, et al., Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene. Nat Genet. 1997 Apr;15(4):397-401
All:	8 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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