Mtrtm1Lcb
Targeted Allele Detail
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| Symbol: |
Mtrtm1Lcb |
| Name: |
5-methyltetrahydrofolate-homocysteine methyltransferase; targeted mutation 1, Lawrence C Brody |
| MGI ID: |
MGI:2180496 |
| Synonyms: |
MS-, Mtr- |
| Gene: |
Mtr Location: Chr13:12197598-12272999 bp, - strand Genetic Position: Chr13, 4.52 cM
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| Alliance: |
Mtrtm1Lcb page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:67384
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129S/SvEv
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Disruption caused by insertion of vector
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Mutation details: A PGK-neo cassette was inserted to delete a region spanning from the middle of exon 3 through exon 6. This deleted region encodes the essential homocysteine binding domain. Reduced levels of transcript were observed in extracts from the liver and kidney of heterozygous mutant mice. Enzyme activity levels in heterozygotes were found to be approximately 60% of wild-type.
(J:67384)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Mtr Mutation: |
50 strains or lines available
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| Original: |
J:67384 Swanson DA, et al., Targeted disruption of the methionine synthase gene in mice. Mol Cell Biol. 2001 Feb;21(4):1058-65 |
| All: |
3 reference(s) |
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Analysis Tools
