Cd1d1<tm1Luc> Targeted Allele Detail MGI Mouse (MGI:2180711)

Cd1d1^tm1Luc
Targeted Allele Detail

Summary

Symbol:	Cd1d1^tm1Luc
Name:	CD1d1 antigen; targeted mutation 1, Luc Van Kaer
MGI ID:	MGI:2180711
Synonyms:	CD1-, cD1d-, CD1d⁰, CD1d1^-, CD1d1⁰
Gene:	Cd1d1 Location: Chr3:86903141-86906748 bp, - strand Genetic Position: Chr3, 37.91 cM
Alliance:	Cd1d1^tm1Luc page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:39748
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: A neomycin selection cassette replaced 200 nucleotides in exon 3 of Cd1d1, while leaving the adjacent Cd1d2 locus intact. Thymocytes derived from homozygous mutant mice were shown to lack protein surface expression. This finding was confirmed by the inability of a specific hybridoma to recognize thymocytes from homozygous mutant mice. (J:39748)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Cd1d1^tm1Luc

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Cd1d1 Mutation:	35 strains or lines available

References

Original:	J:39748 Mendiratta SK, et al., CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity. 1997 APR;6(4):469-477
All:	135 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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