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Tnp2tm1Wen
Targeted Allele Detail
Summary
Symbol: Tnp2tm1Wen
Name: transition protein 2; targeted mutation 1, Wolfgang Engel
MGI ID: MGI:2180779
Synonyms: Tnp2-/-
Gene: Tnp2  Location: Chr16:10605799-10606519 bp, - strand  Genetic Position: Chr16, 5.83 cM, cytoband B1-B3
Alliance: Tnp2tm1Wen page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76986
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 1 upstream of the argnine- and lysine-rich domain via homologous recombination. Northern and Western blot of testes from homozygous mutant mice verified the absence of gene expression. (J:76986)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnp2 Mutation:  5 strains or lines available
References
Original:  J:76986 Adham IM, et al., Teratozoospermia in mice lacking the transition protein 2 (Tnp2). Mol Hum Reprod. 2001 Jun;7(6):513-20
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory