Comp<tm1Aol> Targeted Allele Detail MGI Mouse (MGI:2180787)

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Comp^tm1Aol
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Comp^tm1Aol
Name:	cartilage oligomeric matrix protein; targeted mutation 1, Ake Oldberg
MGI ID:	MGI:2180787
Synonyms:	COMP-null, TSP5 KO
Gene:	Comp Location: Chr8:70826208-70834716 bp, + strand Genetic Position: Chr8, 34.15 cM
Alliance:	Comp^tm1Aol page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:76781
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: The gene was disrupted by insertion of a PGK-neo cassette via homologous recombination into sequences encoding the first type 3 repeat. Northern blot, RT-PCR analysis, and Western blot of RNA and proteins extracted from the processus xiphoideus of homozygous mutant mice verified the absence of gene expression. (J:76781)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Comp Mutation:	37 strains or lines available

References

Original:	J:76781 Svensson L, et al., Cartilage oligomeric matrix protein-deficient mice have normal skeletal development. Mol Cell Biol. 2002 Jun;22(12):4366-71
All:	17 reference(s)

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