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Nodaltm1Rob
Targeted Allele Detail
Summary
Symbol: Nodaltm1Rob
Name: nodal growth differentiation factor; targeted mutation 1, Elizabeth J Robertson
MGI ID: MGI:2180793
Synonyms: Nodal-, nodal-KO, nodal.lacZ, nodallacZ, Nodaltm1Robv
Gene: Nodal  Location: Chr10:61253751-61261117 bp, + strand  Genetic Position: Chr10, 32.21 cM
Alliance: Nodaltm1Rob page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:32935
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A 400 bp segment from the second exon was replaced with an IRES-lacZ and neomycin gene fusion cassette. Beta-galactosidase was expressed from this allele under the control of the endogenous promoter. (J:32935, J:48467)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 198 assay results
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nodal Mutation:  42 strains or lines available
References
Original:  J:32935 Collignon J, et al., Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature. 1996 May 9;381(6578):155-8
All:  59 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory