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Cldn11tm1Ral
Targeted Allele Detail
Summary
Symbol: Cldn11tm1Ral
Name: claudin 11; targeted mutation 1, Robert A Lazzarini
MGI ID: MGI:2181029
Synonyms: OSP/claudin-11 (-)
Gene: Cldn11  Location: Chr3:31204069-31218473 bp, + strand  Genetic Position: Chr3, 15.14 cM
Alliance: Cldn11tm1Ral page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:59025
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A construct containing a promoterless lacZ gene and a floxed PGK-neomycin resistance gene replaced exon 1 and a portion of intron 1. Northern blot analysis of extracts from brains and testes showed a lack of transcript in homozygous mutant mice. Western blot analysis confirmed an absence of encoded protein in brain homogenates. Expression of the inserted lacZ gene was under the control of the endogenous promoter. (J:59025)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cldn11 Mutation:  15 strains or lines available
References
Original:  J:59025 Gow A, et al., CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice. Cell. 1999 Dec 10;99(6):649-59
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory