Bmp4<tm3.1Blh> Targeted Allele Detail MGI Mouse (MGI:2181190)

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Bmp4^tm3.1Blh
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Bmp4^tm3.1Blh
Name:	bone morphogenetic protein 4; targeted mutation 3.1, Brigid L Hogan
MGI ID:	MGI:2181190
Synonyms:	BMP4-fx, Bmp4^loxP-lacZ
Gene:	Bmp4 Location: Chr14:46620982-46628126 bp, - strand Genetic Position: Chr14, 23.95 cM
Alliance:	Bmp4^tm3.1Blh page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:75136
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Conditional ready, Hypomorph, Reporter)
Mutation:		Insertion
		Mutation details: This hypomorphic allele is a derivative of Bmp4^tm3Blh. LoxP sites were inserted flanking exons 3 and 4, and a promoterless lacZ gene was inserted 3' to the loxP insertions. An frt-flanked neomycin selection cassette that was inserted downstream of the lacZ gene was removed by Flpe mediated recombination in the final allele. (J:75136)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Bmp4 Mutation:	23 strains or lines available

References

Original:	J:75136 Kulessa H, et al., Generation of a loxP flanked bmp4(loxP-lacZ) allele marked by conditional lacZ expression. Genesis. 2002 Feb;32(2):66-8
All:	15 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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