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Cd44tm1Mak
Targeted Allele Detail
Summary
Symbol: Cd44tm1Mak
Name: CD44 antigen; targeted mutation 1, Tak W Mak
MGI ID: MGI:2181292
Synonyms: CD44-
Gene: Cd44  Location: Chr2:102641486-102732010 bp, - strand  Genetic Position: Chr2, 54.13 cM
Alliance: Cd44tm1Mak page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72658
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The 3' portion of exon 2 and all of exon 3 were replaced by the insertion of a neomycin resistance cassette. The deleted region encodes part of the invariant amino terminus, common to all isoforms. A lack of protein surface expression was observed in spleen, lymph node, and thymus cells via flow cytometry. (J:72658)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd44 Mutation:  72 strains or lines available
References
Original:  J:72658 Schmits R, et al., CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood. 1997 Sep 15;90(6):2217-33
All:  77 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory