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Pdx1tm2Cvw
Targeted Allele Detail
Summary
Symbol: Pdx1tm2Cvw
Name: pancreatic and duodenal homeobox 1; targeted mutation 2, Christopher VE Wright
MGI ID: MGI:2181362
Synonyms: Ipf1-, pdx-1 -, Pdx12E3-lacZ, pdxlacZko-
Gene: Pdx1  Location: Chr5:147206907-147212658 bp, + strand  Genetic Position: Chr5, 86.84 cM
Alliance: Pdx1tm2Cvw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:32017
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation details: The gene was disrupted by insertion of an in-frame lacZ reporter gene into the 5' end of exon 2 resulting in the deletion of the DNA-binding homeodomain. (J:32017)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 283 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 15 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdx1 Mutation:  35 strains or lines available
References
Original:  J:32017 Offield MF, et al., PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 1996 Mar;122(3):983-95
All:  22 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory