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Hnf1btm2Mya
Targeted Allele Detail
Summary
Symbol: Hnf1btm2Mya
Name: HNF1 homeobox B; targeted mutation 2, Moshe Yaniv
MGI ID: MGI:2181390
Synonyms: Hnf1betadel, vHNF1/del
Gene: Hnf1b  Location: Chr11:83741035-83796743 bp, + strand  Genetic Position: Chr11, 51.23 cM
Alliance: Hnf1btm2Mya page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58080
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A floxed neomycin selection cassette and an additional loxP site were inserted at the endogenous locus via homologous recombination. Deletion of the promoter region, the transcription initiation site, and exon 1 was achieved by the transient expression of cre recombinase in ES cells. (J:58080)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hnf1b Mutation:  16 strains or lines available
References
Original:  J:58080 Coffinier C, et al., Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation. Development. 1999 Nov;126(21):4785-94
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory