Sox2<tm2Skn> Targeted Allele Detail MGI Mouse (MGI:2181440)

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Sox2^tm2Skn
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Sox2^tm2Skn
Name:	SRY (sex determining region Y)-box 2; targeted mutation 2, Silvia K Nicolis
MGI ID:	MGI:2181440
Synonyms:	allele 2, Sox2^Beta-geo
Gene:	Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
Alliance:	Sox2^tm2Skn page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:62026
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1^c

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The entire coding region was replaced by a construct containing a beta-geo fusion gene, lacking a promoter. Recombination of the construct left the 5' flanking region intact, enabling the expression of the beta-geo transgene to be under the control of the endogenous promoter and regulatory sequences. (J:62026)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Sox2 Mutation:	56 strains or lines available

References

Original:	J:62026 Zappone MV, et al., Sox2 regulatory sequences direct expression of a (beta)-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells. Development. 2000 Jun;127(11):2367-82
All:	5 reference(s)

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