Stat5b<tm1Jni> Targeted Allele Detail MGI Mouse (MGI:2181609)

Stat5b^tm1Jni
Targeted Allele Detail

Summary

Symbol:	Stat5b^tm1Jni
Name:	signal transducer and activator of transcription 5B; targeted mutation 1, James N Ihle
MGI ID:	MGI:2181609
Synonyms:	Stat5b-
Gene:	Stat5b Location: Chr11:100671557-100741407 bp, - strand Genetic Position: Chr11, 63.63 cM
Alliance:	Stat5b^tm1Jni page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:77412
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The first exon of the gene was replaced with a neomycin resistance cassette via homologous recombination. Immunoprecipitation and Western blot of liver extracts from homozygous mutant animals verified the absence of gene expression. (J:77412)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	4 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Stat5b Mutation:	33 strains or lines available

Notes

ES cell line = E14 (129P2/OlaHsd) or RW4 (129X1/SvJ).

References

Original:	J:77412 Teglund S, et al., Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell. 1998 May 29;93(5):841-50
All:	23 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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