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Usf2tm1Msw
Targeted Allele Detail
Summary
Symbol: Usf2tm1Msw
Name: upstream transcription factor 2; targeted mutation 1, Michele Sawadogo
MGI ID: MGI:2181680
Synonyms: Usf2(-)
Gene: Usf2  Location: Chr7:30645421-30656288 bp, - strand  Genetic Position: Chr7, 19.27 cM, cytoband A2-B1
Alliance: Usf2tm1Msw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46788
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: 11 kb of the gene, including most of the 5' untranslated region and all of the coding exons, was deleted and replaced with a PGK-neo cassette via homologous recombination. The absence of gene expression in homozygous mutants was confirmed by electrophoretic mobility shift assay (EMSA) and Western blot analysis of nuclear extracts from mutant mouse embryonic fibroblasts (MEF). (J:46788)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Usf2 Mutation:  12 strains or lines available
References
Original:  J:46788 Sirito M, et al., Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3758-63
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory