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Nfatc1tm1Glm
Targeted Allele Detail
Summary
Symbol: Nfatc1tm1Glm
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 1, Laurie H Glimcher
MGI ID: MGI:2181762
Synonyms: NFATc1-
Gene: Nfatc1  Location: Chr18:80649420-80756286 bp, - strand  Genetic Position: Chr18, 53.66 cM, cytoband E4
Alliance: Nfatc1tm1Glm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78376
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Sequence encoding 19 amino acids (635-653) of the Rel-homology domain were replaced by a neomycin selection cassette. A frameshift mutation was introduced into the downstream sequence encoding amino acids 654 through 710. Western blot analysis showed the presence of truncated peptide in homozygous mutant mice. Electromobility shift assays showed a lack of DNA-binding activity. (J:46398, J:78376)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 32 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfatc1 Mutation:  49 strains or lines available
References
Original:  J:78376 Ranger AM, et al., Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity. 1998 Jan;8(1):125-34
All:  20 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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12/10/2024
MGI 6.24 		The Jackson Laboratory