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Nfatc1tm1Mak
Targeted Allele Detail
Summary
Symbol: Nfatc1tm1Mak
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 1, Tak W Mak
MGI ID: MGI:2181766
Synonyms: Nfatc13
Gene: Nfatc1  Location: Chr18:80649420-80756286 bp, - strand  Genetic Position: Chr18, 53.66 cM, cytoband E4
Alliance: Nfatc1tm1Mak page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46399
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin selection cassette replaced exon 3, which encodes amino-terminal serine residues that are involved in nuclear localization. A lack of encoded transcript and protein was determined by northern and western blot analyses of homozygous mutant embryos. (J:46399)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nfatc1 Mutation:  49 strains or lines available
References
Original:  J:46399 de la Pompa JL, et al., Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum [see comments]. Nature. 1998 Mar 12;392(6672):182-6
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory