Ryr3tm1Vso
Targeted Allele Detail
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| Symbol: |
Ryr3tm1Vso |
| Name: |
ryanodine receptor 3; targeted mutation 1, Vincenzo Sorrentino |
| MGI ID: |
MGI:2181794 |
| Synonyms: |
RyR3- |
| Gene: |
Ryr3 Location: Chr2:112461700-113047441 bp, - strand Genetic Position: Chr2, 57.2 cM, cytoband E5-F3
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| Alliance: |
Ryr3tm1Vso page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:45244
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| Parent Cell Line: |
E14 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 6 was replaced with a neomycin resistance gene via homologous recombination resulting in the deletion of the transmembrane domain containing carboxy terminus of the protein. Western blot analysis of microsomal proteins from diaphram muscles confirmed the absence of gene expression in homozygous mutant animals.
(J:45244)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:45244 Bertocchini F, et al., Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles. EMBO J. 1997 Dec 1;16(23):6956-63 |
| All: |
11 reference(s) |
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Analysis Tools
