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Dazltm1Hjc
Targeted Allele Detail
Summary
Symbol: Dazltm1Hjc
Name: deleted in azoospermia-like; targeted mutation 1, Howard J Cooke
MGI ID: MGI:2181904
Synonyms: Dazl-, DazlaTm1Hgu, Dazlko, dazlTm1hgu
Gene: Dazl  Location: Chr17:50586422-50600627 bp, - strand  Genetic Position: Chr17, 25.86 cM, cytoband B1
Alliance: Dazltm1Hjc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42612
Parent Cell Line:  CGR8 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: Exons 5 through 7 were disrupted by the insertion of a neomycin selection cassette. Mutant transcripts were undetected via RT-PCR analysis of total RNA isolated from heterozygous mice. Western blot analysis of testis extracts showed an absence of protein in homozygous mutant mice. (J:42612)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 15 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Dazl Mutation:  32 strains or lines available
References
Original:  J:42612 Ruggiu M, et al., The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis. Nature. 1997 Sep 4;389(6646):73-7
All:  33 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory