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Lhcgrtm1Hht
Targeted Allele Detail
Summary
Symbol: Lhcgrtm1Hht
Name: luteinizing hormone/choriogonadotropin receptor; targeted mutation 1, Ilpo Huhtaniemi
MGI ID: MGI:2181999
Synonyms: LHR -, LuRKO
Gene: Lhcgr  Location: Chr17:89023909-89099418 bp, - strand  Genetic Position: Chr17, 58.35 cM
Alliance: Lhcgrtm1Hht page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66818
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exon 11, which encodes the transmembrane and cytoplasmic receptor domains, was replaced with a neomycin selection gene by homologous recombination. RT-PCR analysis demonstrated that no full length transcript was made in homozygous mice. Radioimmunoassays confirmed that no functional protein was present in homozygous mice. (J:66818)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 27 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lhcgr Mutation:  43 strains or lines available
References
Original:  J:66818 Zhang FP, et al., Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice. Mol Endocrinol. 2001 Jan;15(1):172-83
All:  18 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory