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Slc14a1tm1Ask
Targeted Allele Detail
Summary
Symbol: Slc14a1tm1Ask
Name: solute carrier family 14 (urea transporter), member 1; targeted mutation 1, Alan S Verkman
MGI ID: MGI:2182112
Synonyms: UT-B null, UTB-null
Gene: Slc14a1  Location: Chr18:78143306-78185334 bp, - strand  Genetic Position: Chr18, 52.49 cM
Alliance: Slc14a1tm1Ask page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75466
Parent Cell Line:  CB1-4 (ES Cell)
Strain of Origin:  C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exons 4 and 5 were replaced by a neomycin selection cassette. Truncated transcript was detected via Northern blot analysis, however, immunoblot analysis of erythrocyte extracts and immunohistochemical staining of renal tissue confirmed the absence of protein in homozygous mutant mice. (J:75466)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc14a1 Mutation:  40 strains or lines available
References
Original:  J:75466 Yang B, et al., Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B. J Biol Chem. 2002 Mar 22;277(12):10633-7
All:  11 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory