Csnk2a2<tm1Dcs> Targeted Allele Detail MGI Mouse (MGI:2182135)

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Csnk2a2^tm1Dcs
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Csnk2a2^tm1Dcs
Name:	casein kinase 2, alpha prime polypeptide; targeted mutation 1, David C Seldin
MGI ID:	MGI:2182135
Synonyms:	Csnk2a2-
Gene:	Csnk2a2 Location: Chr8:96172724-96215505 bp, - strand Genetic Position: Chr8, 47.12 cM
Alliance:	Csnk2a2^tm1Dcs page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:57312
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A 2.5kb region, containing the promoter region and exons 1 and 2, was replaced by a neomycin selection cassette. The deleted region encoded the start codon and the ATP-binding domain. Northern and Western blot analyses of testicular tissue showed a lack of transcript and protein in homozygous mutant mice. (J:57312)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Csnk2a2 Mutation:	23 strains or lines available

References

Original:	J:57312 Xu X, et al., Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit. Nat Genet. 1999 Sep;23(1):118-21
All:	4 reference(s)

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