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Ctsgtm1.1Roes
Targeted Allele Detail
Summary
Symbol: Ctsgtm1.1Roes
Name: cathepsin G; targeted mutation 1.1, Jurgen Roes
MGI ID: MGI:2182170
Synonyms: CG-
Gene: Ctsg  Location: Chr14:56337342-56340031 bp, - strand  Genetic Position: Chr14, 28.19 cM
Alliance: Ctsgtm1.1Roes page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77597
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: Transient expression of cre recombinase in ES cells resulted in the excision of a floxed neomycin cassette and a deletion spanning exons 2, 3, and part of 4. Northern and Western blot analyses of bone marrow cells showed an absence of transcript and protein in homozygous mutant mice. (J:77597)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Ctsg Mutation:  13 strains or lines available
References
Original:  J:77597 Tkalcevic J, et al., Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity. 2000 Feb;12(2):201-10
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory