Elanetm1(cre)Roes
Targeted Allele Detail
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| Symbol: |
Elanetm1(cre)Roes |
| Name: |
elastase, neutrophil expressed; targeted mutation 1, Jurgen Roes |
| MGI ID: |
MGI:2182177 |
| Synonyms: |
ElaCre, GE-, GEcre, NE- |
| Gene: |
Elane Location: Chr10:79722146-79724050 bp, + strand Genetic Position: Chr10, 39.72 cM
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| Alliance: |
Elanetm1(cre)Roes page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:77597
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Recombinase) |
| Mutation: |
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Insertion
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Elanetm1(cre)Roes expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: A construct containing a cre recombinase gene, in which GC pairs had been deleted, and a floxed neo gene, was incoporated at the start codon of the endogenous gene. The floxed neo gene was excised in vitro by transiently transfecting ES cells with cre expression vectors. Neither transcript nor protein were detected by Northern and Western blot analyses. Expression of the modified cre transgene permits conditional mutagenesis at sites tagged with loxP in myeloid precursor cells.
(J:77597)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Elane
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:77597 Tkalcevic J, et al., Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity. 2000 Feb;12(2):201-10 |
| All: |
22 reference(s) |
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Analysis Tools
