Cyp1a1tm1.1Dwn
Targeted Allele Detail
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| Symbol: |
Cyp1a1tm1.1Dwn |
| Name: |
cytochrome P450, family 1, subfamily a, polypeptide 1; targeted mutation 1.1, Daniel W Nebert |
| MGI ID: |
MGI:2182307 |
| Synonyms: |
Cyp1a1(-) |
| Gene: |
Cyp1a1 Location: Chr9:57595211-57611107 bp, + strand Genetic Position: Chr9, 31.34 cM
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| Alliance: |
Cyp1a1tm1.1Dwn page
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Dioxin-induced hepatic injury in Cyp1a1tm1.1Dwn/Cyp1a1tm1.1Dwn and Cyp1a2tm1Dwn/Cyp1a2tm1Dwn mice
Show the 1 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:59398
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| Parent Cell Line: |
E14TG2a (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Cre recombinase RNA was injected into zygotes heterozygous for Cyp1a1tm1Dwn. A region containing a floxed HPRT minigene and the entire coding region of Cyp1a1 was excised by cre recombinase. Northern and Western blot analyses of total RNA and protein extracts obtained from animals treated with TCDD (to enhance expression levels) showed an absence of endogenous transcript and normal protein in the livers of homozygous mutant mice.
(J:59398)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:59398 Dalton TP, et al., Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery. Biochem Biophys Res Commun. 2000 Jan 7;267(1):184-9 |
| All: |
30 reference(s) |
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Analysis Tools
