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Zfpm2tm1Jml
Targeted Allele Detail
Summary
Symbol: Zfpm2tm1Jml
Name: zinc finger protein, multitype 2; targeted mutation 1, Jeffrey M Leiden
MGI ID: MGI:2182616
Synonyms: Fog-2-, Zfpm2-
Gene: Zfpm2  Location: Chr15:40518438-40967988 bp, + strand  Genetic Position: Chr15, 15.74 cM, cytoband C
Alliance: Zfpm2tm1Jml page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63121
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The majority of exons 6 and 7 was replaced with a neomycin selection cassette. The replaced region encoded all zinc fingers of the encoded protein. Western blot analysis of homozygous mutant embryonic tissue showed an absence of protein. (J:63121)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 23 assay results
In Structures Affected by this Mutation: 13 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zfpm2 Mutation:  47 strains or lines available
References
Original:  J:63121 Svensson EC, et al., A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2. Nat Genet. 2000 Jul;25(3):353-6
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory