Drgxtm1And
Targeted Allele Detail
|
|
| Symbol: |
Drgxtm1And |
| Name: |
dorsal root ganglia homeobox; targeted mutation 1, David J Anderson |
| MGI ID: |
MGI:2182636 |
| Synonyms: |
Drg11-, Prrxl1- |
| Gene: |
Drgx Location: Chr14:32321364-32371203 bp, + strand Genetic Position: Chr14, 19.4 cM
|
| Alliance: |
Drgxtm1And page
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:70560
|
| Parent Cell Line: |
AB1 (ES Cell)
|
| Strain of Origin: |
129S7/SvEvBrd-Hprt1+
|
|
| Allele Type: |
|
Targeted (Null/knockout) |
| Mutations: |
|
Insertion, Intragenic deletion
|
| |
|
Mutation details: Exons 3 and 4 were replaced with a IRES-Tau-lacZ-neo cassette via homologous recombination. The gene targeting event results in deletion of most of the paired-like homeodomain and putative DNA-binding domain. RT-PCR analysis of homozygous mutant animals was unable to detect gene transcription using primers to the gene coding region or neomycin resistance gene. Amplification products were obtained using primers to the lacZ gene, but lack of beta-gal activity suggests these transcripts were spliced abnormally.
(J:70560)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Drgx Mutation: |
13 strains or lines available
|
|
| Original: |
J:70560 Chen Z, et al., The paired homeodomain protein drg11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron. 2001 Jul 19;31(1):59-73 |
| All: |
9 reference(s) |
|
Analysis Tools
