Agfg1<tm1Jvd> Targeted Allele Detail MGI Mouse (MGI:2182772)

Agfg1^tm1Jvd
Targeted Allele Detail

Summary

Symbol:	Agfg1^tm1Jvd
Name:	ArfGAP with FG repeats 1; targeted mutation 1, Jan M A van Deursen
MGI ID:	MGI:2182772
Synonyms:	Hrb^-
Gene:	Agfg1 Location: Chr1:82817204-82878903 bp, + strand Genetic Position: Chr1, 42.55 cM, cytoband C5
Alliance:	Agfg1^tm1Jvd page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:72756
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A 500 bp region of the gene was replaced with a promoter-less IRES-lacZ-neo cassette via homologous recombination resulting in disruption of the gene at amino acid 108. Absence of gene expression in various tissues from homozygous mutant animals was verified by Western blot analysis. (J:72756)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Agfg1 Mutation:	46 strains or lines available

References

Original:	J:72756 Kang-Decker N, et al., Lack of acrosome formation in hrb-deficient mice. Science. 2001 Nov 16;294(5546):1531-3
All:	5 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24